[51Cr]EDTA intestinal permeability in children with cow's milk intolerance

J Pediatr Gastroenterol Nutr. 1990 Feb;10(2):189-92. doi: 10.1097/00005176-199002000-00008.

Abstract

Making use of [51Cr]EDTA as a permeability marker, we measured intestinal permeability in a group of 20 children with proven cow's milk intolerance (CMI), a group of 17 children with similar complaints where CMI was excluded (sick controls), and a group of 12 control children. [51Cr]EDTA test results (mean +/- SD) were 6.85 +/- 3.64%, 3.42 +/- 0.94%, and 2.61 +/- 0.67% in the group with CMI, the sick control, and the control group, respectively. When compared to both control groups, patients with cow's milk intolerance (CMI) showed a significantly increased small bowel permeability. We conclude that the [51Cr]EDTA test can be helpful for the diagnosis of cow's milk intolerance.

Publication types

  • Clinical Trial

MeSH terms

  • Animals
  • Child
  • Child, Preschool
  • Chromium Radioisotopes*
  • Clinical Trials as Topic
  • Edetic Acid*
  • Female
  • Humans
  • Infant
  • Intestine, Small / metabolism*
  • Lactose Intolerance / diagnosis*
  • Lactose Intolerance / diagnostic imaging
  • Lactose Intolerance / pathology
  • Male
  • Milk / metabolism*
  • Permeability
  • Radionuclide Imaging

Substances

  • Chromium Radioisotopes
  • Edetic Acid