Abstract
The functional characteristics of the DNA fragments responsible for chromosome attachment to the nuclear envelope during the interphase (neDNAs) have been studied. The neDNAs flanking the transgene have been found to promote a steadily high rate of its expression, irrespective of the site of its insertion into the host chromosomes. At the same time, neDNAs themselves have no transcription regulatory functions.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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ATP-Binding Cassette Transporters / genetics
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Animals
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Animals, Genetically Modified
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Chromosomes / physiology*
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DNA / physiology
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Drosophila Proteins / biosynthesis
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Drosophila Proteins / genetics
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Drosophila melanogaster
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Eye Color / genetics
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Eye Proteins / genetics
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Gene Expression Regulation
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Genes, Reporter
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Interphase
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Nuclear Envelope / genetics
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Nuclear Envelope / physiology*
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Nuclear Proteins / genetics*
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Transgenes
Substances
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ATP-Binding Cassette Transporters
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Drosophila Proteins
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Eye Proteins
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Nuclear Proteins
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w protein, Drosophila
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y protein, Drosophila
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DNA