The uptake of paclitaxel and docetaxel into ex vivo porcine bladder tissue from polymeric micelle formulations

Cancer Chemother Pharmacol. 2011 Aug;68(2):431-44. doi: 10.1007/s00280-010-1499-2. Epub 2010 Nov 11.

Abstract

Superficial bladder cancer occurs in the urothelial layer of the bladder and is usually treated by transurethral resection and chemotherapy. Although the bladder is well suited for intravesical chemotherapy, effective drug delivery is restricted by urine dilution and poor drug uptake by bladder tissues during a 2 h instillation. In this study, freshly excised pig bladder sections were mounted on Franz diffusion cells and treated with anticancer drugs paclitaxel (PTX) and docetaxel (DTX) formulated in diblock copolymer (methoxy poly(ethylene glycol)-block-poly (D,L-lactic acid) (MePEG-PDLLA) and methoxy poly(ethylene glycol)-block-poly(caprolactone) (MePEG-PCL) nanoparticles for 2 h. The bladder sections were then frozen, cryosectioned (60-μm sections) and the amount of (3)H drug taken up into each section was determined using liquid scintillation counting. Tissue concentration versus tissue depth profiles were obtained for all drug formulations and drug exposure obtained from area-under-the-curve (AUC) calculations. PTX or DTX loaded in MePEG-PDLLA micelles produced significantly higher urothelial tissue levels and greater bladder wall exposures compared to their commercial formulations, Cremophor EL/ethanol (PTX) or Tween 80 (DTX). The results of this study support the use of diblock copolymer micellar PTX or DTX formulations as they allow for improved drug penetration of bladder tissues compared to commercial formulations for taxane delivery to superficial bladder tumors.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Intravesical
  • Animals
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / analysis
  • Antineoplastic Agents / pharmacokinetics*
  • Biological Transport
  • Docetaxel
  • Drug Carriers / administration & dosage
  • Drug Carriers / analysis
  • Drug Carriers / pharmacokinetics*
  • Drug Compounding
  • Glycerol / analogs & derivatives
  • Glycerol / chemistry
  • In Vitro Techniques
  • Male
  • Micelles
  • Nanoparticles / administration & dosage
  • Paclitaxel / administration & dosage
  • Paclitaxel / analysis
  • Paclitaxel / pharmacokinetics*
  • Pharmaceutical Vehicles / chemistry
  • Polyesters / chemistry
  • Polyethylene Glycols / chemistry
  • Polysorbates / chemistry
  • Swine
  • Taxoids / administration & dosage
  • Taxoids / analysis
  • Taxoids / pharmacokinetics*
  • Tissue Distribution
  • Urinary Bladder / chemistry
  • Urinary Bladder / metabolism*
  • Urinary Bladder Neoplasms / drug therapy

Substances

  • Antineoplastic Agents
  • Drug Carriers
  • Micelles
  • Pharmaceutical Vehicles
  • Polyesters
  • Polysorbates
  • Taxoids
  • methoxy poly(ethylene glycol)-block-poly(lactic acid)
  • methoxy poly(ethylene glycol-co-epsilon-caprolactone)
  • Docetaxel
  • Polyethylene Glycols
  • cremophor EL
  • Paclitaxel
  • Glycerol