Achieving fidelity in homologous recombination despite extreme complexity: informed decisions by molecular profiling

Robert P Rambo; Gareth J Williams; John A Tainer

doi:10.1016/j.molcel.2010.10.032

Achieving fidelity in homologous recombination despite extreme complexity: informed decisions by molecular profiling

Mol Cell. 2010 Nov 12;40(3):347-8. doi: 10.1016/j.molcel.2010.10.032.

Authors

Robert P Rambo¹, Gareth J Williams, John A Tainer

Affiliation

¹ Life Sciences Division, Advanced Light Source, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

Abstract

In this issue of Molecular Cell, Savir and Tlusty (2010) apply signal detection theory to show that homologous recombination machinery is optimally tuned to find homologous DNA sequences within an exceptionally high background of heterologous sequences.

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