Abstract
2-Oxoglutarate oxygenases are inhibited by a range of transition metals, as exemplified by studies on human histone demethylases and prolyl hydroxylase domain 2 (PHD2 or EGLN1). The biological effects associated with 2-oxoglutarate oxygenase inhibition may result from inhibition of more than one enzyme and by mechanisms in addition to simple competition with the Fe(ii) cofactor.
MeSH terms
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Binding, Competitive
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Coenzymes / pharmacology*
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Enzyme Activation / drug effects*
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Histone Demethylases / antagonists & inhibitors
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Humans
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Inhibitory Concentration 50
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Ketoglutaric Acids* / antagonists & inhibitors
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Oxygenases / antagonists & inhibitors*
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Procollagen-Proline Dioxygenase / antagonists & inhibitors
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Transition Elements / pharmacology*
Substances
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Coenzymes
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Ketoglutaric Acids
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Transition Elements
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Oxygenases
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Histone Demethylases
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Procollagen-Proline Dioxygenase