Abstract
The past 15 years have witnessed an enormous effort in studying B-cell Chronic Lymphocytic Leukemia. A great number of researches brought significant novel information and a better understanding of the natural history of this disease. This mini review will focus on the studies related to the Immunoglobulin variable (IgV) genes rearrangements that compose the B-cell receptor (BcR) of the leukemic clones. These studies have defined a role for the antigen(s) in the paths that lead to leukemic clone generation/expansion and underscore the informative value represented by BcR analyses.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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B-Lymphocytes / immunology*
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B-Lymphocytes / metabolism*
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B-Lymphocytes / pathology
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Clone Cells
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Genetic Predisposition to Disease / genetics
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Humans
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Immunoglobulin Variable Region / physiology
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Leukemia, Lymphocytic, Chronic, B-Cell / immunology*
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Leukemia, Lymphocytic, Chronic, B-Cell / metabolism*
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Leukemia, Lymphocytic, Chronic, B-Cell / pathology
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Mutation / genetics
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Receptors, Antigen, B-Cell / genetics
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Receptors, Antigen, B-Cell / physiology*
Substances
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Immunoglobulin Variable Region
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Receptors, Antigen, B-Cell