Tuning in to noise: epigenetics and intangible variation

Nadia C Whitelaw; Suyinn Chong; Emma Whitelaw

doi:10.1016/j.devcel.2010.11.001

Tuning in to noise: epigenetics and intangible variation

Dev Cell. 2010 Nov 16;19(5):649-50. doi: 10.1016/j.devcel.2010.11.001.

Authors

Nadia C Whitelaw¹, Suyinn Chong, Emma Whitelaw

Affiliation

¹ Epigenetics Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia.

PMID: 21074715
DOI: 10.1016/j.devcel.2010.11.001

Abstract

In this special issue of Developmental Cell, we discuss the role of chromatin in phenotypic variation as a counterpoint to the reviews on chromatin dynamics in development and cancer. We highlight some recent work on the role of chromatin in transcriptional noise in yeast and Caenorhabditis elegans and consider the implications in understanding intangible variation or developmental noise in mammals.

MeSH terms

Animals
Caenorhabditis elegans / genetics
Chromatin / metabolism*
Epigenesis, Genetic*
Genetic Variation*
Transcription, Genetic
Yeasts / genetics

Substances

Chromatin