Abstract
The discovery and structure-activity relationship of a novel series of indole-2-carboxamide antagonists of the cannabinoid CB(1) receptor is disclosed. Compound 26i was found to be a high potency, selective cannabinoid CB(1) antagonist.
Copyright © 2010 Elsevier Ltd. All rights reserved.
MeSH terms
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Amides / chemical synthesis
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Amides / chemistry*
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Amides / pharmacokinetics
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Animals
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Dogs
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Drug Evaluation, Preclinical
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Indoles / chemical synthesis
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Indoles / chemistry*
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Indoles / pharmacokinetics
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Male
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Mice
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Models, Molecular
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Rats
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Rats, Wistar
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Receptor, Cannabinoid, CB1 / antagonists & inhibitors*
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Receptor, Cannabinoid, CB1 / metabolism
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Structure-Activity Relationship
Substances
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Amides
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Indoles
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Receptor, Cannabinoid, CB1