Abstract
B cell gut-homing is mainly mediated by α4β7, CCR9 and CCR10. We here studied the expression of these receptors on B cells from cord blood and from peripheral blood at 1, 4, 18 and 36 months of age in a prospective cohort of Swedish infants. The proportion of all B cells expressing α4β7 as well as the fraction of CCR10+ B cells expressing α4β7 was highest in early infancy. Nearly all naïve B cells in all age groups expressed α4β7, whereas the expression on class-switched B cells decreased with age. Moreover, the proportion of both IgA+ and IgG+ B cells expressing α4β7, CCR9 and CCR10 were higher during the first months when compared to adults. In conclusion, the high fraction of circulating IgA+ and IgG+ B cells expressing CCR9 and CCR10 in the first months of life indicates activation of naïve B cells in the gut, coinciding with bacterial colonization.
Copyright © 2010 Elsevier Inc. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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B-Lymphocyte Subsets / cytology
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B-Lymphocyte Subsets / immunology
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B-Lymphocyte Subsets / metabolism
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B-Lymphocytes / cytology
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B-Lymphocytes / immunology
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B-Lymphocytes / metabolism*
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Child, Preschool
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Humans
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Immune System / cytology*
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Immune System / growth & development*
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Immunoglobulin A / metabolism
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Immunoglobulin G / metabolism
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Infant
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Infant, Newborn
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Integrins / metabolism
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Intestines / cytology
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Intestines / immunology*
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Lymphocyte Count
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Middle Aged
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Receptors, CCR / metabolism
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Receptors, CCR10 / metabolism
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Receptors, Lymphocyte Homing / metabolism*
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Tumor Necrosis Factor Receptor Superfamily, Member 7 / metabolism
Substances
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CC chemokine receptor 9
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CCR10 protein, human
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Immunoglobulin A
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Immunoglobulin G
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Integrins
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Receptors, CCR
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Receptors, CCR10
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Receptors, Lymphocyte Homing
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Tumor Necrosis Factor Receptor Superfamily, Member 7
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integrin alpha4beta7