IDH1 mutant structures reveal a mechanism of dominant inhibition

Cell Res. 2010 Dec;20(12):1279-81. doi: 10.1038/cr.2010.160. Epub 2010 Nov 16.
No abstract available

MeSH terms

  • Amino Acid Substitution
  • Dimerization
  • Isocitrate Dehydrogenase / chemistry*
  • Isocitrate Dehydrogenase / genetics
  • Isocitrate Dehydrogenase / metabolism
  • Isocitrates / chemistry
  • Mutation
  • Protein Binding
  • Protein Structure, Tertiary

Substances

  • Isocitrates
  • IDH2 protein, human
  • Isocitrate Dehydrogenase
  • IDH1 protein, human