A click procedure with heterogeneous copper to tether technetium-99m chelating agents and rhenium complexes. Evaluation of the chelating properties and biodistribution of the new radiolabelled glucose conjugates

Carbohydr Res. 2011 Jan 3;346(1):26-34. doi: 10.1016/j.carres.2010.10.011. Epub 2010 Oct 20.

Abstract

An efficient protocol was developed to tether chelating agents and rhenium complexes onto a glucoside scaffold with a heterogeneous copper catalyst via click chemistry. The supported catalyst avoids the formation of unwanted copper complexes during the cyclisation step. The possibility to graft a pre-chelated M(CO)(3) core by click chemistry onto a biomolecule was highlighted for the first time. (99m)Tc(CO)(3)-glucoconjugates displayed excellent in vitro stability, a fast in vivo blood clearance and a low specific organ uptake or long-term retention in spleen and stomach.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chelating Agents / chemistry*
  • Click Chemistry / methods*
  • Copper / chemistry*
  • Glucose / chemistry*
  • Glycoconjugates / chemical synthesis*
  • Glycoconjugates / chemistry
  • Molecular Structure
  • Organotechnetium Compounds / chemical synthesis*
  • Organotechnetium Compounds / chemistry
  • Rhenium / chemistry*
  • Technetium / chemistry*

Substances

  • Chelating Agents
  • Glycoconjugates
  • Organotechnetium Compounds
  • Rhenium
  • Technetium
  • Copper
  • Glucose