iMAT: an integrative metabolic analysis tool

Bioinformatics. 2010 Dec 15;26(24):3140-2. doi: 10.1093/bioinformatics/btq602. Epub 2010 Nov 15.

Abstract

Summary: iMAT is an Integrative Metabolic Analysis Tool, enabling the integration of transcriptomic and proteomic data with genome-scale metabolic network models to predict enzymes' metabolic flux, based on the method previously described by Shlomi et al. The prediction of metabolic fluxes based on high-throughput molecular data sources could help to advance our understanding of cellular metabolism, since current experimental approaches are limited to measuring fluxes through merely a few dozen enzymes.

Availability and implementation: http://imat.cs.tau.ac.il/.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Gene Expression Profiling
  • Genome
  • Metabolic Networks and Pathways*
  • Models, Biological
  • Principal Component Analysis
  • Proteomics
  • Software*