Abstract
A smart miniaturized system is being proposed for the isolation and characterization of circulating tumor cells (CTCs) directly from blood. Different microfluidic modules have been designed for cell enrichment and -counting, multiplex mRNA amplification as well as DNA detection. With the different modules at hand, future effort will focus on the integration of the modules in a fully automated, single platform.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Separation / instrumentation*
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Cell Separation / methods
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Cytophotometry / instrumentation
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Cytophotometry / methods
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DNA, Neoplasm / isolation & purification
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Humans
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Lab-On-A-Chip Devices*
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Neoplasms / blood*
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Neoplasms / genetics
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Neoplasms / pathology
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Neoplastic Cells, Circulating*
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Polymerase Chain Reaction / instrumentation
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Polymerase Chain Reaction / methods