Abstract
Few therapeutic alternatives remain for the treatment of infections due to multiresistant Mycobacterium abscessus. Here we show that the peptidoglycans of the "rough" and "smooth" morphotypes contain predominantly 3→3 cross-links generated by l,d-transpeptidases, indicating that these enzymes are attractive targets for the development of efficient drugs.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacterial Proteins / metabolism*
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Cell Wall / chemistry
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Chromatography, High Pressure Liquid
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Mycobacterium / chemistry
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Mycobacterium / enzymology*
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Mycobacterium / metabolism*
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Peptidoglycan / chemistry
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Peptidoglycan / metabolism*
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Peptidyl Transferases / metabolism*
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Tandem Mass Spectrometry
Substances
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Bacterial Proteins
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Peptidoglycan
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Peptidyl Transferases