The aim of this study was to investigate use of complementary and alternative medicines, and factors that affect use of these agents, in individuals with diabetes. This cross-sectional and descriptive study was performed at the outpatient clinics of four hospitals in Turkey with 396 diabetic individuals between October 2006 and March 2007. In this study, 34.6% of the participants were using complementary and alternative medicine in addition to conventional medicine; 73% of these individuals had not informed their doctors and nurses about their complementary and alternative medicine practice. Nurses, as health care providers, should not ignore complementary and alternative medicine options. Instead, they should try to determine the rate of complementary and alternative medicine use among their patients and understand their effects and the reasons for use of these agents. Nurses should learn more about these medicines and educate their patients.