Abstract
In the last five years, bioluminescence has emerged as a vital tool in the non-invasive quantification of beta-cell mass following islet transplantation in murine models. The successes achieved in bioluminescence imaging in islet transplantation has prompted its use in the discipline of beta-cell regeneration. Employing bioluminescence permits quantifying changes in β-cell mass in an individual mouse over time, which can provide valuable insights into the kinetics of beta-cell regeneration.
MeSH terms
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Animals
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Diagnostic Imaging / methods*
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Disease Models, Animal
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Genes, Reporter
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Insulin / genetics*
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Insulin-Secreting Cells / physiology*
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Islets of Langerhans Transplantation / methods*
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Luciferases / analysis*
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Luciferases / genetics
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Luciferases / metabolism
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Mice
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Mice, SCID
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Mice, Transgenic
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Pancreatic Diseases / diagnosis
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Pancreatic Diseases / pathology
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Pancreatic Diseases / physiopathology
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Pancreatic Diseases / therapy
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Prognosis
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Promoter Regions, Genetic / physiology
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Regeneration / genetics
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Regeneration / physiology*