Comparison of alpha-blocker, extracorporeal magnetic stimulation alone and in combination in the management of female bladder outlet obstruction

Int Urogynecol J. 2011 Jul;22(7):849-54. doi: 10.1007/s00192-010-1322-y. Epub 2010 Nov 25.

Abstract

Introduction and hypothesis: To determine the effects of alpha-blocker, extracorporeal magnetic innervations (ExMI) alone and combination treatment on female bladder outlet obstruction (BOO).

Methods: Sixty women with BOO were divided into three groups according to the treatment. After 3 months, the clinical outcomes were evaluated by clinical examination, international prostatic symptom score (IPSS), quality of life (QOL), 3-day voiding diary, uroflowmetry and post-void residual.

Results: At 3 months, symptom improvement was 52.6% in alpha-blocker monotherapy (group I), 50.0% in ExMI monotherapy (group II), and 57.1% in combination therapy (group III). Maximum flow rate increased and total IPSS decreased significantly in all groups (p < 0.05). Storage symptom subscore was more reduced in groups II and III and QOL improved significantly in group III (p < 0.05)

Conclusions: This study demonstrates that both alpha-blocker and ExMI were effective in female BOO, and ExMI may be more effective for improving storage symptoms.

Publication types

  • Controlled Clinical Trial

MeSH terms

  • Adrenergic alpha-Antagonists / therapeutic use*
  • Adult
  • Combined Modality Therapy
  • Female
  • Humans
  • Magnetic Field Therapy*
  • Middle Aged
  • Prospective Studies
  • Quality of Life
  • Quinazolines / therapeutic use*
  • Surveys and Questionnaires
  • Treatment Outcome
  • Urinary Bladder Neck Obstruction / drug therapy*
  • Urinary Bladder Neck Obstruction / therapy
  • Urodynamics*

Substances

  • Adrenergic alpha-Antagonists
  • Quinazolines
  • alfuzosin