ATP consumption promotes cancer metabolism

William J Israelsen; Matthew G Vander Heiden

doi:10.1016/j.cell.2010.11.010

ATP consumption promotes cancer metabolism

Cell. 2010 Nov 24;143(5):669-71. doi: 10.1016/j.cell.2010.11.010.

Authors

William J Israelsen¹, Matthew G Vander Heiden

Affiliation

¹ Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, 02139, USA.

PMID: 21111226
DOI: 10.1016/j.cell.2010.11.010

Abstract

Cancer cells metabolize glucose by aerobic glycolysis, a phenomenon known as the Warburg effect. Fang et al. (2010) show that the endoplasmic reticulum enzyme ENTPD5 promotes ATP consumption and favors aerobic glycolysis. The findings suggest that nutrient uptake in cancer cells is limited by ATP and satisfies energy requirements other than ATP production.

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