Routes to manipulate MHC class II antigen presentation

Tineke van den Hoorn; Petra Paul; Marlieke L M Jongsma; Jacques Neefjes

doi:10.1016/j.coi.2010.11.002

Routes to manipulate MHC class II antigen presentation

Curr Opin Immunol. 2011 Feb;23(1):88-95. doi: 10.1016/j.coi.2010.11.002. Epub 2010 Nov 25.

Authors

Tineke van den Hoorn¹, Petra Paul, Marlieke L M Jongsma, Jacques Neefjes

Affiliation

¹ Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, Netherlands.

PMID: 21112200
DOI: 10.1016/j.coi.2010.11.002

Abstract

MHC class II molecules (MHC-II) present antigenic fragments acquired in the endocytic route to the immune system for recognition and activation of CD4+ T cells. This ignites a series of immune responses. MHC-II strongly correlates to most autoimmune diseases. Understanding the biology of MHC-II is therefore expected to translate into novel means of autoimmunity control or immune response improvement. Although the basic cell biology of MHC-II antigen presentation is well understood, many novel aspects have been uncovered in recent years including means of antigen delivery, preparation for MHC-II loading, transport processes and vaccination strategies. We will discuss past, present and future of these insights into the biology of MHC-II.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Antigen Presentation*
Cell Membrane / immunology
Cell Membrane / metabolism
Histocompatibility Antigens Class II / immunology*
Histocompatibility Antigens Class II / metabolism
Humans
Protein Transport
Vaccination

Substances

Histocompatibility Antigens Class II