Effect of acute and chronic buspirone administration on communicativeness of mice with experience of defeats in social conflicts

Bull Exp Biol Med. 2010 Jul;149(1):57-61. doi: 10.1007/s10517-010-0875-6.
[Article in English, Russian]

Abstract

We studied the effect of 5-HT(1A)receptor agonist buspirone on behavior of male C57Bl/6J mice in the "partition" test, which reflects communicativeness of animals. Single administration of buspirone (1 mg/kg) to intact mice and animals experienced defeats in 20 intermale confrontations impaired their communicativeness, especially in intact animals. On the contrary, administration of buspirone (1 mg/kg) to losers starting from day 5 of intermale confrontations for 2 weeks produced a positive effect and prevented impairment of communicativeness by day 20 of confrontations. The role of brain 5-HT(1A)receptors in these processes is discussed.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animal Communication*
  • Animals
  • Buspirone / administration & dosage
  • Buspirone / pharmacology*
  • Conflict, Psychological*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Receptor, Serotonin, 5-HT1A / metabolism
  • Social Behavior*
  • Statistics, Nonparametric
  • Time Factors

Substances

  • Receptor, Serotonin, 5-HT1A
  • Buspirone