Synthesis and in vitro cytotoxic evaluation of some thiazolylbenzimidazole derivatives

Yu Luo; Feng Xiao; Shijing Qian; Wei Lu; Bo Yang

doi:10.1016/j.ejmech.2010.11.014

Synthesis and in vitro cytotoxic evaluation of some thiazolylbenzimidazole derivatives

Eur J Med Chem. 2011 Jan;46(1):417-22. doi: 10.1016/j.ejmech.2010.11.014. Epub 2010 Nov 27.

Authors

Yu Luo¹, Feng Xiao, Shijing Qian, Wei Lu, Bo Yang

Affiliation

¹ Department of Chemistry, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, China.

PMID: 21115212
DOI: 10.1016/j.ejmech.2010.11.014

Abstract

A novel kind of thiazolylbenzimidazole derivatives were designed and synthesized and evaluated for their antitumor activity against SMMC-7721 and A549 cell lines. Most compounds showed good antitumor activities, and compound 11b displayed remarkable in vitro anticancer activity comparable to taxol. The preliminary structure-activity relationship of these benzimidazole derivatives was discussed based on the experimental data obtained.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis
Antineoplastic Agents / chemistry*
Antineoplastic Agents / pharmacology*
Antineoplastic Agents / toxicity
Benzimidazoles / chemical synthesis
Benzimidazoles / chemistry*
Benzimidazoles / pharmacology*
Benzimidazoles / toxicity
Cell Line, Tumor
Drug Screening Assays, Antitumor
Humans
Inhibitory Concentration 50
Structure-Activity Relationship

Substances

Antineoplastic Agents
Benzimidazoles