Electrochemical properties of myoglobin deposited on multi-walled carbon nanotube/ciprofloxacin film

Colloids Surf B Biointerfaces. 2011 Feb 1;82(2):526-31. doi: 10.1016/j.colsurfb.2010.10.011. Epub 2010 Oct 15.

Abstract

We report the direct electrochemical and electrocatalytic properties of myoglobin (MB) on a multi-walled carbon nanotube/ciprofloxacin (MWCNT/CF) film-modified electrode. A highly homogeneous MWCNT thin-film was prepared on an electrode surface using ciprofloxacin (CF) as a dispersing agent. MB was then electrochemically deposited onto the MWCNT/CF-modified electrode. The MB/MWCNT/CF film was characterized by scanning electron microscopy and UV-visible spectroscopy (UV-vis). UV-vis spectra confirmed that MB retained its original state on the MWCNT/CF film. Direct electrochemical properties of MB on the MWCNT/CF film were investigated by cyclic voltammetry. The formal potential and electron transfer rate constant were evaluated in pH 7.2 buffer solution as -0.327V and 300s(-1), respectively. In addition, the MB/MWCNT/CF-modified electrode showed excellent electrocatalytic properties for the reduction of hydrogen peroxide (H(2)O(2)). The MB/MWCNT/CF-modified electrode was used for the detection of H(2)O(2) at concentrations from 1×10(-6)M to 7×10(-4)M in pH 7.2 buffer solution. Overall, the MB/MWCNT/CF-modified electrode was very stable and has potential for development as a H(2)O(2) sensor.

MeSH terms

  • Animals
  • Anti-Infective Agents / pharmacology
  • Biosensing Techniques
  • Catalysis
  • Ciprofloxacin / pharmacology*
  • Electrochemistry / methods*
  • Horses
  • Hydrogen Peroxide / chemistry
  • Hydrogen-Ion Concentration
  • Kinetics
  • Models, Chemical
  • Myocardium / metabolism
  • Myoglobin / chemistry*
  • Nanotechnology / methods*
  • Nanotubes, Carbon / chemistry*
  • Spectrophotometry, Ultraviolet / methods

Substances

  • Anti-Infective Agents
  • Myoglobin
  • Nanotubes, Carbon
  • Ciprofloxacin
  • Hydrogen Peroxide