Abstract
A highly enantioselective three-component reaction of a diazoacetophenone, an alcohol, and an imine catalyzed cooperatively by Rh(2)(OAc)(4) and BINOL-derived chiral phosphoric acid has been developed for the synthesis of chiral β-amino-α-hydroxyl ketones in good yield with excellent diastereo and enantio selectivity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetophenones / chemistry*
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Alcohols / chemistry*
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Azo Compounds / chemistry*
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Catalysis
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Imines / chemistry*
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Mannich Bases / chemistry*
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Naphthols / chemistry
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Phosphoric Acids / chemistry
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Rhodium / chemistry
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Stereoisomerism
Substances
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Acetophenones
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Alcohols
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Azo Compounds
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BINOL, naphthol
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Imines
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Mannich Bases
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Naphthols
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Phosphoric Acids
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Rhodium
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phosphoric acid
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acetophenone