The objective of this study was to examine which factors are associated with increased cancer knowledge among a sample of 866 Arab Americans 40 years of age or older. Individuals were invited to attend a cancer educational intervention and obtain a free cancer health screening. They were asked to complete a precancer and postcancer knowledge survey after the brief educational intervention. Using logistic regression, we found that the intervention increased cancer knowledge and the variables most associated with this improvement were having low education, being unemployed, having lived in the USA for 0-5 years, older age, not having insurance, and not exercising. Our study showed that these interventions may be more effective if tailored to the participant's educational, employment, duration in the US, and health behavior status. Future studies should examine whether cancer screening actually increases after an educational intervention.