Background: It is hypothesized that inflammatory response after subarachnoid hemorrhage (SAH) may play a relevant role in the development and maintenance of vasospasm. This research investigated the correlation between IL-6 in cerebrospinal fluid (CSF) after SAH and the occurrence of vasospasm.
Methods: We analyzed both daily clinical manifestation and laboratory data of CSF in 46 patients who suffered from intracranial aneurismal subarachnoid hemorrhage during a period of 14 days, studied the relationship between the development of vasospasm and the quantities of the inflammatory factor, revealing potential power of IL-6 for predicting vasospasm detected by transcranial doppler (TCD).
Results: The incidence of vasospasm developed in 43.5% of the patients, with a mean onset of 6.1±4.6 days after intracranial aneurysm treatment. Patients with vasospasm demonstrated statistically significant higher median values of IL-6CSF on Day 1, 2, 3, 5 and 7 (P<0.05). The cut-off value is settled in 400 pg/ml on Day 3 after treatment. On the other hand, gender, Hunt & Hess scale (H&H) and Fisher scale of CT after SAH were proved to be the correlation factor with vasospasm.
Conclusion: IL-6CSF seems to be a reliable early marker for predicting vasospasm after subarachnoid hemorrhage on Days 3 after treatment before clinical onset.