Abstract
To identify oseltamivir resistance, we analyzed neuraminidase H275Y mutations in samples from 10 patients infected with pandemic (H1N1) 2009 virus in South Korea who had influenza that was refractory to antiviral treatment with this drug. A neuraminidase I117M mutation that might influence oseltamivir susceptibility was detected in sequential specimens from 1 patient.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Substitution
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Antiviral Agents / pharmacology
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Antiviral Agents / therapeutic use*
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Child, Preschool
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Disease Outbreaks*
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Drug Resistance, Viral
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Female
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Humans
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Infant
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Influenza A Virus, H1N1 Subtype / drug effects*
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Influenza A Virus, H1N1 Subtype / genetics*
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Influenza, Human / drug therapy*
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Influenza, Human / epidemiology
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Influenza, Human / virology
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Male
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Middle Aged
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Molecular Epidemiology
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Molecular Sequence Data
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Neuraminidase / genetics*
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Oseltamivir / pharmacology
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Oseltamivir / therapeutic use*
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Republic of Korea / epidemiology
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Viral Proteins / genetics
Substances
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Antiviral Agents
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Viral Proteins
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Oseltamivir
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Neuraminidase
Associated data
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GENBANK/CY060453
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GENBANK/CY060454
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GENBANK/CY060455
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GENBANK/CY060456
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GENBANK/CY060457
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GENBANK/CY060458
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GENBANK/CY060459
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GENBANK/CY060460
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GENBANK/CY060461
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GENBANK/CY060462
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GENBANK/CY060463
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GENBANK/CY060464
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GENBANK/CY060465
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GENBANK/CY060466
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GENBANK/CY060467
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GENBANK/CY060468
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GENBANK/CY060469
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GENBANK/CY060470
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GENBANK/CY060471
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GENBANK/CY060472
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GENBANK/CY060473
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GENBANK/CY060474
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GENBANK/CY060475
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GENBANK/CY060476
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GENBANK/CY060477
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GENBANK/CY060478
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GENBANK/CY060479
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GENBANK/CY060480
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GENBANK/CY060481
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GENBANK/CY060482
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GENBANK/CY060483
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GENBANK/CY060484
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GENBANK/CY060485
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GENBANK/CY060486
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GENBANK/CY060487
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GENBANK/CY060495
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GENBANK/CY060496
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GENBANK/CY060497
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GENBANK/CY060498