Abstract
This second section of the first ECCO pathogenesis workshop on anti-TNF therapy failures in inflammatory bowel diseases addresses the biological roles of TNFα and the effects and mechanisms of action of TNFα antagonists. Mechanisms underlying their failure, including induction of TNF-independent inflammatory pathways and phenomena of paradoxical inflammation are discussed.
Copyright © 2010 European Crohn's and Colitis Organisation. All rights reserved.
MeSH terms
-
Animals
-
Antibodies, Monoclonal / pharmacology
-
Antibodies, Monoclonal / therapeutic use
-
Colitis, Ulcerative / drug therapy
-
Colitis, Ulcerative / immunology
-
Colitis, Ulcerative / physiopathology
-
Crohn Disease / drug therapy
-
Crohn Disease / immunology
-
Crohn Disease / physiopathology
-
Humans
-
Inflammatory Bowel Diseases / drug therapy*
-
Inflammatory Bowel Diseases / immunology
-
Inflammatory Bowel Diseases / physiopathology
-
Interferon-alpha / physiology
-
Interleukin-17 / physiology
-
Interleukin-23 / physiology
-
Mice
-
NK Cell Lectin-Like Receptor Subfamily K / physiology
-
Treatment Failure
-
Tumor Necrosis Factor-alpha / antagonists & inhibitors*
-
Tumor Necrosis Factor-alpha / physiology
Substances
-
Antibodies, Monoclonal
-
Interferon-alpha
-
Interleukin-17
-
Interleukin-23
-
NK Cell Lectin-Like Receptor Subfamily K
-
Tumor Necrosis Factor-alpha