Increased plasma methylglyoxal level, inflammation, and vascular endothelial dysfunction in diabetic nephropathy

Clin Biochem. 2011 Mar;44(4):307-11. doi: 10.1016/j.clinbiochem.2010.11.004. Epub 2010 Nov 30.

Abstract

Objectives: To investigate the association of plasma levels of methylglyoxal (MG) and markers of inflammation/endothelial dysfunction with diabetic nephropathy (DN).

Design and methods: Plasma levels of MG, cytokines, and adhesion molecules were measured in type 2 diabetic patients (T2DM), T2DM patients with DN, and the controls.

Results: Plasma MG levels in DN were significantly higher than those in T2DM and the controls (312 ± 135 vs. 212 ± 73 and 312 ± 135 vs. 147 ± 78 nmol/L, respectively, P<0.001). The plasma levels of MG were positively correlated with the fasting glucose, HbA1c, and urinary albumin/creatinine ratio (r=0.754, P<0.05). Plasma levels of IL-6, TNF-α, and adhesion molecules were markedly increased in DN compared to T2DM patients and the controls.

Conclusions: Increased plasma levels of MG, cytokines, and adhesion molecules are associated with DN. These markers may be useful in predicting the development of DN.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Albumins / analysis
  • Biomarkers / analysis
  • Blood Glucose / analysis
  • Case-Control Studies
  • Cell Adhesion Molecules / blood
  • Creatinine / urine
  • Diabetic Nephropathies / blood*
  • Diabetic Nephropathies / physiopathology
  • Endothelium, Vascular / metabolism*
  • Endothelium, Vascular / physiopathology
  • Female
  • Glycated Hemoglobin / analysis
  • Humans
  • Inflammation / blood
  • Interleukin-6 / blood
  • Male
  • Middle Aged
  • Plasma / chemistry
  • Pyruvaldehyde / blood
  • Tumor Necrosis Factor-alpha / blood

Substances

  • Albumins
  • Biomarkers
  • Blood Glucose
  • Cell Adhesion Molecules
  • Glycated Hemoglobin A
  • Interleukin-6
  • Tumor Necrosis Factor-alpha
  • hemoglobin A1c protein, human
  • Pyruvaldehyde
  • Creatinine