Abstract
Upon apoptosis induction, translocation of mammalian mitochondrial endonuclease G (EndoG) to the nucleus coincides with large-scale DNA fragmentation. Here, we describe for the first time a homologue of EndoG in filamentous fungi by investigating if the Aspergillus nidulans homologue of the EndoG gene, named nucA(EndoG), is being activated during farnesol-induced cell death. Our results suggest that NucA is not involved in cell death, but it plays a role in the DNA-damaging response in A. nidulans.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Apoptosis / drug effects
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Aspergillus nidulans / enzymology*
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DNA Damage
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Endodeoxyribonucleases / genetics
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Endodeoxyribonucleases / metabolism*
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Farnesol / pharmacology
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Fungal Proteins / genetics
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Fungal Proteins / metabolism*
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Gene Deletion
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Gene Expression Regulation, Fungal
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Mitochondrial Proteins / genetics
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Mitochondrial Proteins / metabolism*
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Phenotype
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Recombinant Fusion Proteins / genetics
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Recombinant Fusion Proteins / metabolism*
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Up-Regulation
Substances
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Fungal Proteins
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Mitochondrial Proteins
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Recombinant Fusion Proteins
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Farnesol
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Endodeoxyribonucleases