Noxa: a sweet twist to survival and more

Alfredo Gimenez-Cassina; Nika N Danial

doi:10.1016/j.molcel.2010.11.037

Noxa: a sweet twist to survival and more

Mol Cell. 2010 Dec 10;40(5):687-8. doi: 10.1016/j.molcel.2010.11.037.

Authors

Alfredo Gimenez-Cassina¹, Nika N Danial

Affiliation

¹ Department of Cancer Biology and Division of Metabolism and Chronic Disease, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

PMID: 21145478
DOI: 10.1016/j.molcel.2010.11.037

Abstract

The BCL-2 family member Noxa induces apoptosis by antagonizing the prosurvival protein MCL-1. In this issue of Molecular Cell, Lowman et al. (2010) uncover a glucose-dependent phosphoregulatory mechanism that inactivates Noxa's apoptotic function and triggers its capacity to modulate glucose metabolism.

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