Abstract
Precursor-fed cultivation of endophytic Chaetomium globosum 1C51 afforded nine novel "unnatural" halogenated chaetoglobosins including those with more preferable immunosuppressive activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cells, Cultured
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Chaetomium / chemistry
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Halogenation
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Immunosuppressive Agents / chemical synthesis
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Immunosuppressive Agents / chemistry*
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Immunosuppressive Agents / toxicity
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Indole Alkaloids / chemical synthesis
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Indole Alkaloids / chemistry*
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Indole Alkaloids / toxicity
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Magnetic Resonance Spectroscopy
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Mice
Substances
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Immunosuppressive Agents
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Indole Alkaloids
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chaetoglobosins