Compartmentalization of TNF-receptor 1 signaling: TNF-R1-associated caspase-8 mediates activation of acid sphingomyelinase in late endosomes

Adv Exp Med Biol. 2011:691:605-16. doi: 10.1007/978-1-4419-6612-4_64.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis
  • Caspase 8 / metabolism*
  • Cathepsin D / metabolism
  • Cell Compartmentation*
  • Death Domain Receptor Signaling Adaptor Proteins / metabolism
  • Endocytosis
  • Endosomes / enzymology*
  • Enzyme Activation
  • Humans
  • Mice
  • Models, Biological
  • Protein Processing, Post-Translational
  • Receptors, Tumor Necrosis Factor, Type I / metabolism*
  • Signal Transduction*
  • Sphingomyelin Phosphodiesterase / metabolism*

Substances

  • Death Domain Receptor Signaling Adaptor Proteins
  • Receptors, Tumor Necrosis Factor, Type I
  • Sphingomyelin Phosphodiesterase
  • Caspase 8
  • Cathepsin D