Background: The skin wart is a benign proliferation of the skin and mucous, secondary to human papillomavirus (HPV) infection.
Objectives: The objective of this study is to determine gene frequencies of HLA-DR alleles in Mexican patients with skin warts and compare them with those present in ethnically matched healthy subjects.
Methods: Fifty-two patients with clinically and histologically confirmed skin warts from the Dermatology Outpatient Clinic, with results of high-resolution DNA typing for HLA-DR polymorphism.
Results: HLA-DR3 and DR9 were increased (P = 0.0029, OR: 2.5, 95% CI: 1.3–4.7 and P = 0.0062, OR: 5.4, 95% CI: 1.4–19.5, respectively), and HLA-DR6 allele was found decreased (P = 0.0002).
Limitations: The major histocompatibility complex contribution in the infection and elimination of the virus is not clear and perhaps also contributes to a series of events not well established yet.
Conclusions: This study follows the preponderant role of class II genes in the susceptibility or resistance to the development of skin warts caused by HPV infection.