New library of aminosulfonyl-tagged Hoveyda-Grubbs type complexes: Synthesis, kinetic studies and activity in olefin metathesis transformations

Beilstein J Org Chem. 2010 Dec 6:6:1159-66. doi: 10.3762/bjoc.6.132.

Abstract

Seven novel Hoveyda-Grubbs precatalysts bearing an aminosulfonyl function are reported. Kinetic studies indicate an activity enhancement compared to Hoveyda's precatalyst. A selection of these catalysts was investigated with various substrates in ring-closing metathesis of dienes or enynes and cross metathesis. The results demonstrate that these catalysts show a good tolerance to various chemical functions.

Keywords: RCM; cross-metathesis; kinetic studies; olefin metathesis; ruthenium.