Fasting serum fatty acid-binding protein 4 level positively correlates with metabolic syndrome in hemodialysis patients

Background and aims: Serum fatty acid-binding protein 4 (FABP4) level increases in patients with metabolic syndrome (MetS). The interrelationships between fasting FABP4 levels and MetS have not been analyzed in hemodialysis (HD) patients.

Methods: Fasting blood samples were obtained from 101 chronic HD patients. MetS was defined according to the diagnostic criteria of the International Diabetes Federation.

Results: In total, 48 HD patients (47.5%) had MetS. Fasting FABP4 levels positively correlated with MetS (p = 0.022). Univariate linear regression analysis showed that the pre-HD body weight (p <0.001), waist circumference (p = 0.003), body mass index (p = 0.003), total cholesterol (TCH) (p <0.001), triglyceride (TG) (p <0.001), creatinine (p = 0.042), insulin level (p = 0.014), and homeostasis model assessment of insulin resistance (HOMA-IR; p = 0.015) were positively correlated with serum FABP4 levels, whereas high-density lipoprotein-cholesterol (HDL-C) (p = 0.049) and adiponectin level (p = 0.004) were negatively correlated with fasting serum FABP4 levels in HD patients.

Conclusions: MetS was positively correlated with fasting FABP4 levels in our chronic HD patients. TG, TCH, and waist circumference were independent predictors of serum FABP4 levels in HD patients.