No influence of PTGS2 polymorphisms on response and remission to antidepressants in major depression

Alessandro Serretti; Alberto Chiesa; Raffaella Calati; Isabelle Massat; Sylvie Linotte; Siegfried Kasper; Yves Lecrubier; Martin Fink; Irina Antonijevic; Carlos Forray; Lenore Snyder; Joseph Bollen; Joseph Zohar; Diana De Ronchi; Daniel Souery; Julien Mendlewicz

doi:10.1016/j.psychres.2010.11.023

No influence of PTGS2 polymorphisms on response and remission to antidepressants in major depression

Psychiatry Res. 2011 Jun 30;188(1):166-9. doi: 10.1016/j.psychres.2010.11.023. Epub 2010 Dec 18.

Authors

Alessandro Serretti¹, Alberto Chiesa, Raffaella Calati, Isabelle Massat, Sylvie Linotte, Siegfried Kasper, Yves Lecrubier, Martin Fink, Irina Antonijevic, Carlos Forray, Lenore Snyder, Joseph Bollen, Joseph Zohar, Diana De Ronchi, Daniel Souery, Julien Mendlewicz

Affiliation

¹ Institute of Psychiatry, University of Bologna, Bologna, Italy. [email protected]

PMID: 21168919
DOI: 10.1016/j.psychres.2010.11.023

Abstract

In the present study, aimed at investigating whether a set of single nucleotide polymorphisms (SNPs) within PTGS2 gene (rs4648276, rs2066826 and rs689466) could be associated with antidepressant response, remission and treatment resistance in a sample of major depression patients, we did not find evidence supporting any of such associations.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Antidepressive Agents / therapeutic use*
Chi-Square Distribution
Cyclooxygenase 2 / genetics*
Depressive Disorder, Major / drug therapy*
Depressive Disorder, Major / genetics*
Female
Humans
Male
Middle Aged
Pharmacogenetics
Polymorphism, Single Nucleotide / genetics*

Substances

Antidepressive Agents
Cyclooxygenase 2
PTGS2 protein, human