Abstract
Co-culture of rat retinal pigment epithelial (RPE) cells or retinal capillary endothelial (EC) cells with T lymphocytes from immunised syngeneic rats indicated that RPE cells but not EC could process retinal S-antigen and induce antigen specific T cell activation. Activation of lymphocytes by EC however was also antigen independent, and may be due to T cell (CD2) endothelial cell (LFA-3) ligand interactions which are functional on EC but not RPE.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antigen-Presenting Cells / immunology*
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Antigens / immunology
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Antigens / isolation & purification
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Arrestin
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Blood-Retinal Barrier / immunology*
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Endothelium, Vascular / cytology
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Endothelium, Vascular / immunology*
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Eye Proteins / immunology
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Eye Proteins / isolation & purification
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Interferon-gamma / immunology
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Lymphocyte Activation / immunology*
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Mycobacterium tuberculosis / immunology
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Pigment Epithelium of Eye / cytology
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Pigment Epithelium of Eye / immunology*
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Rats
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Retinal Vessels / cytology
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Retinal Vessels / immunology
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T-Lymphocytes / immunology*
Substances
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Antigens
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Arrestin
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Eye Proteins
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Interferon-gamma