Abstract
Highly efficient preparations of anticancer β-elemene and other bioactive elemanes were carried out using the natural product germacrone as a renewable starting material. The syntheses were achieved in only 3-5 steps with excellent overall yields (43-54%). An enantioselective approach to these molecules is also described.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Catalysis
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Molecular Structure
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Palladium / chemistry
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Sesquiterpenes / chemical synthesis*
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Sesquiterpenes, Germacrane / chemistry*
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Stereoisomerism
Substances
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Antineoplastic Agents
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Sesquiterpenes
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Sesquiterpenes, Germacrane
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beta-elemene
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Palladium
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germacrone