Background: The occurrence of cancer needs many kinds of oncogenes and their cooperation, such as Bcl-2, p27, and vascular endothelial growth factor (VEGF) etc. They have different contributions in lung cancer's occurrence and development by different paths. In this study the expression of P27, Bcl-2, VEGF and their relationship in lung cancer were investigated.
Methods: The expression of P27, Bcl-2 and VEGF was detected in 85 lung cancer and 21 benign pulmonary tissues by the immunohistochemistry staining.
Results: Positive rate of VEGF and Bcl-2 protein expression was 65.88% (56/85) and 61.18% (52/85) respectively in lung cancer tissue, which was higher than that in benign pulmonary tissues (14.29% and (19.05%)) (P < 0.05). Positive rate of P27 protein expression in lung cancer tissue (37.65%, 32/85) was significantly lower than that in benign pulmonary tissues (80.95%, 17/21) (P < 0.05). VEGF expression was closely related to the grade of cell differentiation, P-TNM stage and lymph node status; Bcl-2 expression was closely related to histology of lung cancer, P-TNM stage and grade of cell differentiation; and P27 expression was closely related to grade of cell differentiation. There was correlation between P27 and Bcl-2 and between P27 and VEGF protein, but no correlation between Bcl-2 and VEGF.
Conclusions: Detection of P27, Bcl-2 and VEGF will be valuable for dignosing lung cancer and evaluating malignancy extent.