The efficacy and safety of pravastatin, compared to and in combination with bile acid binding resins, in familial hypercholesterolaemia

J Intern Med. 1990 Sep;228(3):261-6. doi: 10.1111/j.1365-2796.1990.tb00229.x.

Abstract

Forty patients with familial hypercholesterolaemia (FH) were treated with 40 mg pravastatin once daily. Pravastatin decreased serum total and low density lipoprotein cholesterol (LDL) after 8 weeks of treatment by 28% and 33%, respectively, while high density lipoprotein cholesterol increased by 8% and triglycerides decreased by 14%. In 30 patients LDL cholesterol had not decreased below 5.0 mmol l-1 after 8 weeks of treatment, and in these patients resins were added to pravastatin, resulting in an additional decrease in total and LDL cholesterol of 8% and 12%, respectively. A control group of 22 FH patients was treated with placebo for 10 weeks, after which time resins were added, and they induced a decrease in total and LDL-cholesterol of 17% and 22%, respectively. Our results over a 24-week treatment period indicate that 40 mg pravastatin is more effective than 3 packets of resins in lowering LDL cholesterol, whereas the combination is most effective of all and can be used safely.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anticholesteremic Agents / adverse effects
  • Anticholesteremic Agents / therapeutic use
  • Bile Acids and Salts / therapeutic use*
  • Carrier Proteins / therapeutic use*
  • Cholesterol, HDL / blood
  • Cholesterol, LDL / blood
  • Double-Blind Method
  • Drug Administration Schedule
  • Drug Therapy, Combination
  • Female
  • Heptanoic Acids / adverse effects
  • Heptanoic Acids / therapeutic use*
  • Humans
  • Hydroxysteroid Dehydrogenases*
  • Hyperlipoproteinemia Type II / drug therapy*
  • Male
  • Membrane Glycoproteins*
  • Naphthalenes / adverse effects
  • Naphthalenes / therapeutic use*
  • Pravastatin
  • Randomized Controlled Trials as Topic
  • Triglycerides / blood

Substances

  • Anticholesteremic Agents
  • Bile Acids and Salts
  • Carrier Proteins
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Heptanoic Acids
  • Membrane Glycoproteins
  • Naphthalenes
  • Triglycerides
  • bile acid binding proteins
  • Hydroxysteroid Dehydrogenases
  • AKR1C2 protein, human
  • Pravastatin