Seven-year review of prostate carcinomas diagnosed by TRUS biopsy in a single Malaysian institution

Asian Pac J Cancer Prev. 2010;11(5):1351-3.

Abstract

Introduction: Analysis of epidemiological as well as survival differences among the multiethnic population of Malaysia with prostate cancer is important.

Methods: Patients confirmed by transrectal-ultrasonographic-guided-biopsy performed from 2002 to 2008 were enrolled and analysed according to ethnicity, age, PSA level, Gleason score, stage of disease and survival.

Results: Among 83 patients, there were 38 Malay, 40 Chinese, 3 Indians and 2 others. Median age at diagnosis was 69.9 (range: 59-93), 43 patients (51.8%) being diagnosed before the age of 70. The median PSA level upon diagnosis was 574 ng/ml (range: 1-8632) and the median Gleason score was 7 (range: 2-10). Over half were already in Stage 4 when diagnosed. The most common site of metastasis was the bone. As a result the commonest prescribed treatment was hormonal manipulation. Five patients underwent radical prostatectomy and a further thirteen patients had radical radiotherapy (stage I: 1 patient, stage II: 7 patients and stage III: 5 patients). Ten patients defaulted follow-up. The median disease-specific survival was 21.9 months (range: 1-53).

Conclusions: Prostatic carcinoma is a disease of the elderly and it is frequently diagnosed late in Malaysia. Greater efforts should be made to educate Malaysians regarding prostate cancer.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Biopsy
  • Disease-Free Survival
  • Humans
  • Malaysia / epidemiology
  • Malaysia / ethnology
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Prostate-Specific Antigen / blood
  • Prostatic Neoplasms / blood
  • Prostatic Neoplasms / epidemiology
  • Prostatic Neoplasms / pathology*
  • Prostatic Neoplasms / therapy
  • Retrospective Studies

Substances

  • Prostate-Specific Antigen