Abstract
We report 2 cases of acute non-lymphocytic leukemia with distinct clinical and karyotypic features shared by therapy-related acute non-lymphocytic leukemia occurring after adjuvant chemotherapy including 5-fluorouracil, doxorubicin and mitomycin C. Our observation suggests a causal relationship between exposure to mitomycin C and the occurrence of acute non-lymphocytic leukemia.
MeSH terms
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Adenocarcinoma / drug therapy*
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Aged
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Anemia, Refractory, with Excess of Blasts / chemically induced
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Antineoplastic Combined Chemotherapy Protocols / adverse effects*
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Doxorubicin / administration & dosage
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Doxorubicin / adverse effects
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Fluorouracil / administration & dosage
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Fluorouracil / adverse effects
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Humans
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Leukemia, Myeloid, Acute / chemically induced*
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Lung Neoplasms / drug therapy*
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Male
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Middle Aged
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Mitomycin
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Mitomycins / administration & dosage
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Mitomycins / adverse effects*
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Neoplasms, Multiple Primary*
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Stomach Neoplasms / drug therapy*
Substances
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Mitomycins
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Mitomycin
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Doxorubicin
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Fluorouracil