Solid-State Forms of β-Resorcylic Acid: How Exhaustive Should a Polymorph Screen Be?

Cryst Growth Des. 2011 Jan 5;11(1):210-220. doi: 10.1021/cg101162a. Epub 2010 Nov 30.

Abstract

An extensive experimental screen, coupled with a computational study, revealed seven new solid-state forms of β-resorcylic acid. The known, stable polymorph II° shows a reversible phase transformation to the new, kinetically stable, probably disordered high temperature form I. The study provides a consistent picture of the solid-state of β-resorcylic acid.