EROS: Better than SAXS!

Sichun Yang; Benoît Roux

doi:10.1016/j.str.2010.12.008

EROS: Better than SAXS!

Structure. 2011 Jan 12;19(1):3-4. doi: 10.1016/j.str.2010.12.008.

Authors

Sichun Yang¹, Benoît Roux

Affiliation

¹ Center for Proteomics and Department of Pharmacology, Case Western Reserve University, Biomedical Research Building, 10900 Euclid Avenue, Cleveland, OH 44106, USA. [email protected]

PMID: 21220109
DOI: 10.1016/j.str.2010.12.008

Abstract

Revealing the three-dimensional organization of large dynamic protein complexes in solution is challenging. To tackle this problem, Różycki and colleagues (2011) design a method combining small angle X-ray scattering (SAXS) data with the results of computer simulations. Their study offers new insights into the conformational transition induced by salt that occurs in an endosome-associated ESCRT-III CHMP3 domain.

Publication types

Comment

Grants and funding

R01 CA093577/CA/NCI NIH HHS/United States