Response to temozolomide in patients with metastatic colorectal cancer with loss of MGMT expression: a new approach in the era of personalized medicine?

MeSH terms

• Adenocarcinoma / diagnosis
• Adenocarcinoma / drug therapy*
• Adenocarcinoma / enzymology
• Adenocarcinoma / secondary
• Aged
• Antineoplastic Agents, Alkylating / therapeutic use*
• Biopsy
• Colectomy
• Colorectal Neoplasms / diagnosis
• Colorectal Neoplasms / enzymology
• Colorectal Neoplasms / pathology*
• Colorectal Neoplasms / surgery
• DNA Modification Methylases / analysis*
• DNA Repair Enzymes / analysis*
• Dacarbazine / analogs & derivatives*
• Dacarbazine / therapeutic use
• Down-Regulation
• Female
• Humans
• Immunohistochemistry
• Liver Neoplasms / diagnosis
• Liver Neoplasms / drug therapy*
• Liver Neoplasms / enzymology
• Liver Neoplasms / secondary
• Lymphatic Metastasis
• Male
• Middle Aged
• Neoplasm Staging
• Positron-Emission Tomography
• Precision Medicine*
• Temozolomide
• Tomography, X-Ray Computed
• Treatment Outcome
• Tumor Suppressor Proteins / analysis*