Abstract
A 42-year-old man with advanced rectal cancer underwent a low anterior resection with TME and pelvic lateral lymph-node and paraaortic lymph-node dissections. Pathological examination revealed as Type 2, 84 × 70 mm, tub 2 > por, A-SE, int, INF b, ly3, v1, pN3 (35/68), M1 (No. 216: 24/37), Stage IV (Cur B) by Japanese Classification of Colorectal Carcinoma. Three kinds of chemotherapy, 3 courses of irinotecan and bolus fluorouracil plus Leucovorin (IFL), 4 courses of irinotecan and S-1 (IRIS), and one-year of S-1 were administered sequentially. After 5 years from the operation, the patient survived and showed no sign of recurrence. Aggressive lymph-node dissection for rectal cancer patients with massive lymph-node metastasis followed by intensive chemotherapy may result in long-term survival.
MeSH terms
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Adult
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Antimetabolites, Antineoplastic / administration & dosage
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Antineoplastic Agents, Phytogenic / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Aorta, Abdominal
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Camptothecin / administration & dosage
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Camptothecin / analogs & derivatives
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Combined Modality Therapy
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Disease-Free Survival
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Drug Administration Schedule
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Drug Combinations
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Fluorouracil / administration & dosage
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Humans
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Irinotecan
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Leucovorin / administration & dosage
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Lymph Node Excision
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Lymphatic Metastasis / pathology*
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Male
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Oxonic Acid / administration & dosage
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Pelvis
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Rectal Neoplasms / mortality
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Rectal Neoplasms / pathology*
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Rectal Neoplasms / therapy
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Tegafur / administration & dosage
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Vitamin B Complex / administration & dosage
Substances
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Antimetabolites, Antineoplastic
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Antineoplastic Agents, Phytogenic
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Drug Combinations
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Vitamin B Complex
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S 1 (combination)
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Tegafur
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Oxonic Acid
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Irinotecan
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Leucovorin
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Fluorouracil
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Camptothecin