Questioning the value of (99m)Tc-HYNIC-annexin V based response monitoring after docetaxel treatment in a mouse model for hereditary breast cancer

Chantal A C Beekman; Tessa Buckle; Anne C van Leeuwen; Renato A Valdés Olmos; Marcel Verheij; Sven Rottenberg; Fijs W B van Leeuwen

doi:10.1016/j.apradiso.2010.12.012

Questioning the value of (99m)Tc-HYNIC-annexin V based response monitoring after docetaxel treatment in a mouse model for hereditary breast cancer

Appl Radiat Isot. 2011 Apr;69(4):656-62. doi: 10.1016/j.apradiso.2010.12.012. Epub 2010 Dec 25.

Authors

Chantal A C Beekman¹, Tessa Buckle, Anne C van Leeuwen, Renato A Valdés Olmos, Marcel Verheij, Sven Rottenberg, Fijs W B van Leeuwen

Affiliation

¹ Division of Diagnostic Oncology, Netherland Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.

PMID: 21227707
DOI: 10.1016/j.apradiso.2010.12.012

Abstract

Annexin V imaging is suggested to provide a good indication of cancer treatment efficacy. To study the accuracy of (99m)Tc-AnxV imaging, we monitored chemo-sensitive and chemo-resistant tumors in a mouse breast cancer model after treatment with docetaxel. Sensitive tumors showed a slight peak in (99m)Tc-AnxV uptake one day post-treatment, while uptake in resistant tumors remained constant. In contrast to immunohistochemical analysis, (99m)Tc-AnxV imaging could not be used to predict tumor response, due to large variation between animals.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Annexin A5*
Breast Neoplasms / diagnostic imaging*
Breast Neoplasms / drug therapy
Breast Neoplasms / genetics
Disease Models, Animal
Docetaxel
Mice
Organotechnetium Compounds*
Radionuclide Imaging
Taxoids / therapeutic use

Substances

Annexin A5
Organotechnetium Compounds
Taxoids
Docetaxel