Axonal neuropathy with monoclonal IgG kappa that binds to a neurofilament protein

R Nemni; M L Feltri; R Fazio; A Quattrini; I Lorenzetti; M Corbo; N Canal

doi:10.1002/ana.410280309

Axonal neuropathy with monoclonal IgG kappa that binds to a neurofilament protein

Ann Neurol. 1990 Sep;28(3):361-4. doi: 10.1002/ana.410280309.

Authors

R Nemni¹, M L Feltri, R Fazio, A Quattrini, I Lorenzetti, M Corbo, N Canal

Affiliation

¹ Department of Neurology, University of Milan, Istituto Scientifico S. Raffaele, Italy.

PMID: 2122795
DOI: 10.1002/ana.410280309

Abstract

We report a 74-year-old woman with a slowly progressive sensory motor axonal neuropathy and a monoclonal IgG-kappa that bound to a 68-kd axonal protein identified as the low molecular weight neurofilament protein. The sera of control subjects and disease controls did not bind to neurofilament protein.

Publication types

Case Reports

MeSH terms

Aged
Axons*
Electrophysiology
Female
Humans
Immunoblotting
Immunoglobulin G / metabolism*
Immunoglobulin kappa-Chains / metabolism*
Intermediate Filament Proteins / metabolism*
Nervous System Diseases / metabolism*
Nervous System Diseases / pathology
Nervous System Diseases / physiopathology
Paraproteinemias / metabolism*
Sural Nerve / pathology

Substances

Immunoglobulin G
Immunoglobulin kappa-Chains
Intermediate Filament Proteins