Abstract
Purpose:
To retrospectively report the outcome of head and neck cancer patients following re-irradiation.
Patients and methods:
A total of 51 patients with recurrent or second primary head and neck cancer received re-irradiation at Leuven University Hospital. Survival and locoregional control were calculated. Doses to organs at risk were retrieved from dose-volume histograms. Radiation-related toxicities were reported.
Results:
The 2-year actuarial overall survival rate was 30%. On univariate analysis, surgery before re-irradiation and high radiation dose were associated with superior survival. Grade 3 acute and grade 3 or more late toxicity occurred in respectively 29.4% and 35.3% of the patients.
Conclusion:
Re-irradiation in head and neck cancer patients is feasible with acceptable late toxicity, although the survival remains poor.
MeSH terms
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Adult
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Aged
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Brachytherapy
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Chemotherapy, Adjuvant
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Combined Modality Therapy
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Female
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Follow-Up Studies
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Humans
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Lymphatic Metastasis / pathology
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Lymphatic Metastasis / radiotherapy
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Male
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Middle Aged
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Neoplasm Recurrence, Local / diagnostic imaging
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Neoplasm Recurrence, Local / mortality
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Neoplasm Recurrence, Local / pathology
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Neoplasm Recurrence, Local / radiotherapy*
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Neoplasm Staging
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Neoplasms, Second Primary / diagnostic imaging
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Neoplasms, Second Primary / mortality
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Neoplasms, Second Primary / pathology
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Neoplasms, Second Primary / radiotherapy*
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Otorhinolaryngologic Neoplasms / diagnostic imaging
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Otorhinolaryngologic Neoplasms / mortality
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Otorhinolaryngologic Neoplasms / pathology
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Otorhinolaryngologic Neoplasms / radiotherapy*
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Radiation Injuries / etiology*
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Radiotherapy Dosage
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Radiotherapy Planning, Computer-Assisted
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Radiotherapy, Conformal
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Retreatment
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Survival Rate
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Tomography, X-Ray Computed
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Tumor Burden