Abstract
New perspectives for radiosensitization in hepatocellular carcinoma (HCC) have emerged with the increasing knowledge of mechanisms involved in liver oncogenesis. As a matter of fact, some of these mechanisms have also a role in the response to ionizing radiation. We review some of the major molecular pathways involved in the oncogenesis of hepatocellular carcinoma. These include cellular proliferation pathways, repair systems, apoptosis, and angiogenesis. However, there are few preclinical data on concurrent targeted therapies and ionizing radiation in hepatocellular carcinoma models. Preliminary studies are ongoing. Their results might help to better define the potential benefit of such radiosensitizing strategies in the management of hepatocellular carcinoma.
Copyright © 2010 Société française de radiothérapie oncologique (SFRO). Published by Elsevier SAS. All rights reserved.
MeSH terms
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Carcinoma, Hepatocellular / genetics*
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Carcinoma, Hepatocellular / radiotherapy
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ErbB Receptors / genetics
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ErbB Receptors / metabolism
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Humans
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Intercellular Signaling Peptides and Proteins / genetics
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Intercellular Signaling Peptides and Proteins / metabolism
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Liver Neoplasms / genetics*
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Liver Neoplasms / radiotherapy
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Neovascularization, Pathologic
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Poly (ADP-Ribose) Polymerase-1
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Poly(ADP-ribose) Polymerases / genetics
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Poly(ADP-ribose) Polymerases / metabolism
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Protein Kinases / genetics
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Protein Kinases / metabolism
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Receptor, IGF Type 2 / genetics
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Receptor, IGF Type 2 / metabolism
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Tumor Suppressor Proteins / genetics
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Tumor Suppressor Proteins / metabolism
Substances
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Intercellular Signaling Peptides and Proteins
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Receptor, IGF Type 2
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Tumor Suppressor Proteins
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PARP1 protein, human
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Poly (ADP-Ribose) Polymerase-1
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Poly(ADP-ribose) Polymerases
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Protein Kinases
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ErbB Receptors